The most effective natural Rheumatoid Arthritis treatment
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What is Rhematoid arthritis?

Rheumatoid arthritis (RA) is on of the most common forms of arthritis. RA is a chronic disease that causes inflammation of the joints and surrounding tissue. The late phase of RA is characterized by destruction of cartilage, which leads to deformity. The cause of RA is unknown.

RA is diagnosed through a combination of joint x-rays and blood tests to screen for the presence of specific markers, specifically the anti-CCP (anti-cyclic citrullinated peptide antibody) test.

The rheumatoid factor test is usually positive including the anti-keratin antibody and anti-ANCA (neutrophil cytoplasmic antibody) test. Today, no known conventional, curative treatment exists. Long-term use of traditionally prescribed medications has adverse side effects.

Several studies have shown that patients suffering from RA have a shortened life span. This could very possibly be related to their highly elevated level of oxidative stress. A long list of natural anti-inflammatory and antioxidant nutrients have shown to have positive effects on RA patients. Moreover, they have no side effects and are therefore a preferred alternative to conventional medicine. Medical acupuncture has also shown to have a significant effect on finger joint pain.

Which natural ingredients can have an effect on rheumatoid arthritis?

Chondroitin sulfate, glucosamine sulfate, methylsulfonylmethane (MSM), ginger root extract, vitamins B5, C, E and folic acid, carotenoids, magnesium, copper, zinc, selenium and grape seed extract.

What effects do these ingredients have?

  • Reduce pain.
  • Reduce edema.
  • Stimulate the growth of cartilage, unlike NSAIDs, which may inhibit growth.
  • Improve joint mobility.
  • Prevent deformation of joints.
  • Can often inhibit further development of RA.

For the reader with a deeper interest:

How do these ingredients work?

  • Treat and prevent vitamin and mineral deficiencies.
  • Rebuild destroyed cartilage.
  • Reduce risk of oxidative tissue damage.
  • Inhibit the production of the tumor necrosis factor (TNF) 1beta.
  • Inhibit the production of interleukin (IL) 1beta.
  • Inhibit the production of leukotriene B4 from stimulating neutrophil granulocytes.
  • Inhibit lipoxygenase synthesis.
  • Inhibit cyclooxygenase-2 (COX-2) synthesis.
  • Inhibit the synthesis of eukotriene B4 and prostaglandin E2.
  • Stimulate the production of proteoglycans.

The information above is based on more than 25,000 articles published in scientific journals and which are available at MEDLINE, the world’s largest medical database. Below you will find a few of them listed:

References

  1. Ariza-Ariza R, Mestanza-Peralta M, Cardiel MH. Omega-3 fatty acids in rheumatoid arthritis: an overview.* Seminars in Arthritis and Rheumatism. 1998;27(6):366-370.
  2. Astin JA. Mind-body therapies for the management of pain.* Clinical Journal of Pain. 2004;20(1):27-32.
  3. Beckermann B, Beneke M, Seitz I. Comparison of bioavailability of EPA and DHA from triglycerides, free fatty acids and ethyl ester after single oral administration to 8 female volunteers. Biochemische Eutwicklung 1988;S1:298–30.
  4. Belch JJF, Ansell D, Madhok R, Dowd AO, Sturock RD. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Ann Rheum Dis 1988;47:96–104.
  5. Berbert AA, Kondon CR, Almendra AL, et al. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.* Nutrition. 2005;2:131-136.
  6. Berman JD, Straus SE. Implementing a research agenda in complementary and alternative medicine.* Annual Review of Medicine. 2004;55:239-254.
  7. Bigaouette J, Timchalk MA, Kremer JM. Nutritional adequacy of diet and supplements in patients with rheumatoid arthritis taking medication. J Am Diet Assoc 1987;87:11–2.
  8. Capriotti T. Any science behind the hype of "natural" dietary supplements?* Medsurg Nursing. 2004;13(5):339-350.
  9. Casimiro L, Brosseau L, Milne S, et al. Acupuncture and electroacupuncture for the treatment of RA. Cochrane Database of Systematic Reviews. 2004;(3):CD003788. Accessed on January 26, 2004.
  10. Cleland LG, French JK, Betts WH, Murphy GA, Elliott MJ. Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. J Rheumatol 1988;15:1471–5.
  11. Cleland LG, James MJ, Proudman SM. The role of fish oils in the treatment of rheumatoid arthritis.* Drugs. 2003;63(9):845-853.
  12. Cleland, Leslie G. and James, Michael J. Fish oil and rheumatoid arthritis: antiinflammatory and collateral health benefits. Journal of Rheumatology, Vol. 27, October 2000, pp. 2305-06 (editorial).
  13. Cleland, Leslie G., et al. Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. American Journal of Clinical Nutrition, Vol. 55, February 1992, pp. 395-99.
  14. Conn DL, Arnold WH, Hollister JR. Alternative treatments and rheumatic diseases.* Bulletin on the Rheumatic Diseases. 1999;48(7):1-4.
  15. Curtis CL, Harwood JL, Dent CM, et al. Biological basis for the benefit of nutraceutical supplementation in arthritis.* Drug Discovery Today. 2004;9(4):165-172.
  16. Danao-Camara TC, Shintani TT. The dietary treatment of inflammatory arthritis: case reports and review of the literature.* Hawaii Medical Journal. 1999;58(5):126-131.
  17. Darlington LG, Ramsey N, Mansfield J. Placebo controlled, blind study of dietary manipulation therapy in rheumatoid arthritis. Lancet I:236-238, 1986.
  18. Darlington LG. Dietary therapy for arthritis. Rheumatic Diseases Clinics of North America17(2):273-286, 1991.
  19. Darlington, L. Gail and Stone, Trevor W. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. British Journal of Nutrition, Vol. 85, March 2001, pp. 251-69.
  20. Denman AM, Mitchell B, Ansell B. Joint complaints and food allergic disorders.
  21. Donadio JV, Bergstrath EJ, Offord KP, Spenser DC, Holley KE. A controlled trial of fish oil in IgA nephropathy. N Engl J Med 1994;331:1194–9.
  22. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. Journal of Rheumatology, Vol. 27, October 2000, pp. 2343-46.
  23. Endres S, Ghorbani R, Kelley VE, et al. The effects of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265–71.
  24. Ernst E. Usage of complementary therapies in rheumatology: a systematic review.* Clinical Rheumatology. 1998;17(4):301-305.
  25. Fisher P, Scott DL. A randomized controlled trial of homeopathy in rheumatoid arthritis.* Rheumatology (Oxford). 2001;40(9):1052-1055.
  26. Fortin PR, Lew RA, Liang MH, et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis.* Journal of Clinical Epidemiology. 1995;48(11):1379-1390.
  27. Fortin PR, Liang MH, Beckett LA, et al. A meta-analysis of the efficacy of fish oil in rheumatoid arthritis. Arthritis Rheum 1992;35:S201 (abstr).
  28. Fortin, Paul R., et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. Journal of Clinical Epidemiology, Vol. 48, 1995, pp. 1379-90.
  29. Geusens P, Wouters C, Nijs J, Jiang Y, Dequeker J. Long-term effect of n-3 fatty acid supplementation in active rheumatoid arthritis: a 12 month double blind controlled study. Arthritis Rheum 1994;37:824–9.
  30. Geusens, Piet, et al. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. Arthritis & Rheumatism, Vol. 37, June 1994, pp. 824-29.
  31. Hafstrom I, Ringertz B, Spangberg A, et al. A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens.* Rheumatology (Oxford). 2001;40(10):1175-1179.
  32. Henderson CJ, Panush RS. Diets, dietary supplements, and nutritional therapies in rheumatic diseases.* Rheumatic Disease Clinics of North America. 1999;25(4):937-968.
  33. Hudnall M. Illness and Disease Vitamins, Minerals and Dietary Supplements 1999 Minneapolis, MN: Chronimed, 42-44.
  34. James MF, Proudman SM, Cleland LG. Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis.* Prostaglandins, Leukotrienes and Essential Fatty Acids. 2003;68(6):399-405.
  35. Jonas WB, Linde K, Ramirez G. Homeopathy and rheumatic diseases.* Rheumatic Disease Clinics of North America. 2000;26(1):117-123.
  36. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Oystein F. Controlled trial of fasting and one year vegetarian diet in rheumatoid arthritis. Lancet 338:899-902, 1991.
  37. Kjeldsen-Kragh J, Hvatum M, Haugen M, Forre O, Scott H. Antibodies against dietary antigens in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet. Clinical Experimental Rheumatology 13(2):167-172, 1995.
  38. Kjeldsen-Kragh J, Lund JA, Riise T, et al. Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. J Rheumatol 1992;19:1531–6.
  39. Kremer JM, Biguouette J, Michalek AU. Effects of manipulating dietary fatty acids on clinical manifestations of rheumatoid arthritis. Lancet 1985;1:184–7.
  40. Kremer JM, Jubiz W, Michalek A, et al. Fish oil fatty acid supplementation in active rheumatoid arthritis: a double-blinded, controlled crossover study. Ann Intern Med 1987;106:497–503.
  41. Kremer JM, Lawrence DA, Jubiz W, et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis Rheum 1990;33:810–20.
  42. Kremer JM, Lawrence DA, Petrillo GF, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs: clinical and immune correlates. Arthritis Rheum 1995;38:1107–14.
  43. Kremer JM. Clinical studies of n-3 fatty acid supplementation in patients with rheumatoid arthritis. Rheum Dis Clin North Am 1992;17:391–402.
  44. Kremer JM. Nutrition in the rheumatic disease. In: Textbook of rheumatology. 5th ed. Philadelphia: WB Saunders, 1997:521–33.
  45. Kremer, Joel M. n-3 fatty acid supplements in rheumatoid arthritis. American Journal of Clinical Nutrition, Vol. 71 (suppl), January 2000, pp. 349S-51S.
  46. Lau CS, Morely KD, Belch JJ. Effects of fish oil supplementation on the non-steroidal anti-inflammatory drug requirements in patients with mild rheumatoid arthritis: a double blind placebo controlled study. Br J Rheumatol 1993;32:982–9.
  47. Lee TH, Hoover RL, Williams JD, et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on the in vitro neutrophil and monocyte leukotrienic generation and neutrophil function. N Engl J Med 1985;312:1217–24.
  48. Lewis RA, Austin KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. N Engl J Med 1990;323:645–55.
  49. Little C, Parsons T. Herbal therapy for treating rheumatoid arthritis. Cochrane Database of Systematic Reviews. 2004;(1):CD002948. Accessed on January 26, 2004.
  50. Luley C, Wieland H, Grunwald J. Bioavailability of omega-3 fatty aids: ethylester preparations are as suitable as triglyceride preparations. Aktuelle Eruahr Med 1990;15:123–35.
  51. Martin RH. The role of nutrition and diet in rheumatoid arthritis.* Proceedings of the Nutrition Society. 1998;57(2):231-234.
  52. Morgan SL, Baggott JE, Vaughn WH, William H, Austin JS, Veitech TA, Lee JY, Koopman WJ, Krumdieck CL, Alarcon GS. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis: a double-blind, placebo-controlled trial.
  53. National Center for Complementary and Alternative Medicine. Questions and Answers: NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT). National Center for Complementary and Alternative Medicine Web site. Accessed on July 28, 2005.
  54. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Arthritis Treatment and Research: Rheumatoid Arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH SeniorHealth Web site. Accessed on January 7, 2005.
  55. Natural Medicines Comprehensive Database. Black Currant. Natural Medicines Comprehensive Database Web site. Accessed on September 29, 2004.
  56. Natural Medicines Comprehensive Database. Borage Seed Oil. Natural Medicines Comprehensive Database Web site. Accessed on September 29, 2004.
  57. Natural Medicines Comprehensive Database. Chondroitin Sulfate. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  58. Natural Medicines Comprehensive Database. Evening Primrose Oil. Natural Medicines Comprehensive Database Web site. Accessed on September 29, 2004.
  59. Natural Medicines Comprehensive Database. Feverfew. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  60. Natural Medicines Comprehensive Database. Fish Oil. Natural Medicines Comprehensive Database Web site. Accessed on May 17, 2004.
  61. Natural Medicines Comprehensive Database. Gamma-Linolenic Acid. Natural Medicines Comprehensive Database Web site. Accessed on August 18, 2004.
  62. Natural Medicines Comprehensive Database. Ginger. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  63. Natural Medicines Comprehensive Database. Glucosamine Sulfate. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  64. Natural Medicines Comprehensive Database. Indian Frankincense. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  65. Natural Medicines Comprehensive Database. Thunder God Vine. Natural Medicines Comprehensive Database Web site. Accessed on August 18, 2004.
  66. Natural Medicines Comprehensive Database. Turmeric. Natural Medicines Comprehensive Database Web site. Accessed on July 7, 2005.
  67. Natural Medicines Comprehensive Database. Valerian. Natural Medicines Comprehensive Database Web site. Accessed on July 6, 2005.
  68. Natural Standard Database. Valerian (Valeriana officinalis L.). Natural Medicines Comprehensive Database Web site. Accessed on August 19, 2005.
  69. Navarro, Elisabet, et al. Abnormal fatty acid pattern in rheumatoid arthritis - A rationale for treatment with marine and botanical lipids. Journal of Rheumatology, Vol. 27, February 2000, pp. 298-303.
  70. Nielsen GI, Faarvang KL, Thomsen BS, et al. The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial. Eur J Clin Invest 1992;22:687–91.
  71. Nutrition and Your Health: Dietary Guidelines for Americans. U.S. Department of Agriculture, U.S. Department of Health and Human Services. 4th edition, 1995.
  72. Office of Dietary Supplements. Vitamin A and Carotenoids. Office of Dietary Supplements Web site. Accessed on August 11, 2004.
  73. Oh R. Practical applications of fish oil (omega-3 fatty acids) in primary care.* Journal of the American Board of Family Practice. 2005;18(1):28-36.
  74. Palmblad J, Hafstrom I, Ringertz B. Antirheumatic effects of fasting. Rheumatic Diseases Clinics of North America 17(2):351-362, 1991.
  75. Panush RS. American College of Rheumatology position statement: diet and arthritis.* Rheumatic Disease Clinics of North America. 1991;17(2):443-444.
  76. Panush RS. Does food cause or cure arthritis? Rheumatic Diseases Clinics of North America 17(2):259-272, 1991.
  77. Panush RS. Does food cause or cure arthritis?* Rheumatic Disease Clinics of North America. 1991;17(2):259-272.
  78. Pattrick M, Heptinstall S, Doherty M. Feverfew in rheumatoid arthritis: a double blind, placebo controlled study.* Annals of the Rheumatic Diseases. 1989. 48(7):547-549.
  79. Prickett JD, Robinson DR, Steinberg AD. Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW f1 mice. J Clin Invest 1981;68:556–9.
  80. Prickett JD, Trentham DE, Robinson DR. Dietary fish oil augments the induction of arthritis in rats immunized with type II collagen. J Immunol 1984;132:725–9.
  81. Rao JK, Mihaliak K, Kroenke K, et al. Use of complementary therapies for arthritis among patients of rheumatologists.* Annals of Internal Medicine. 1999;131(6):409-416.
  82. Rennie KL, Hughes J, Lang R, et al. Nutritional management of rheumatoid arthritis: a review of the evidence.* Journal of Human Nutrition and Dietetics. 2003;16(2):97-109.
  83. Robinson DR, Prickett JD, Makoul GT, Steinberg AD, Colvin RB. Dietary fish oil reduces progression of established renal disease in (NZB x NZW) F1 mice and delays renal disease in BXDB and MRL/1 strains. Arthritis Rheum 1986;29:539–46.
  84. Robinson DR, Tateno S, Balkrishna P, Hirai A. Lipid mediators of inflammatory and immune reactions. JPEN J Parenter Enteral Nutr 1988;12:375–425.
  85. Robinson DR, Tateno S, Knoell C, et al. Dietary marine lipids suppress murine autoimmune disease. J Intern Med 1989;225(suppl):211–6.
  86. Roubenoff R, Freeman LM, Smith DE, Abad LW, Dinarello CA, Kehayias JJ. Adjuvant arthritis as a model of inflammatory cachexia. Arthritis and Rheumatism 40(3):534-539, 1997.
  87. Schlaepfer TE, Kosel M, Nemeroff CB. Efficacy of transcranial magnetic stimulation (rTMS) in the treatment of affective disorders.* Neuropsychopharmacology. 2003;28(2):201-205.
  88. Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.* Seminars in Arthritis and Rheumatology. 2005;34(6):773-784.
  89. Sherman, M. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunological effects. Arthritis Rheum 1 33(6):810-20, 1990.
  90. Skoldstam L, Borjesson O, Kjllman A, Seiving B, Akesson B. Effect of six months of fish oil supplementation in stable rheumatoid arthritis: a double blind, controlled study. Scand J Rheumatol 1992;21:178–85.
  91. Skoldstam L, Hagfors L, Johansson G. An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis.* Annals of the Rheumatic Diseases. 2003;62(3):208-214.
  92. Skoldstam L, Magnusson KE. Fasting, intestinal permeability and rheumatoid arthritis. Rheumatic Diseases Clinics of North America 17(2):363-371, 1991.
  93. Soeken KL, Miller SA, Ernst E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review.* Rheumatology (Oxford). 2003;42(5):652-659.
  94. Soeken KL. Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews.* 2004. Clinical Journal of Pain. 2004;20(1):13-18.
  95. Somer E. Vitamins, Minerals and Disease. The essential guide to vitamins and minerals. 1995 New York: HarperCollins, pgs.174-177.
  96. Sperling RI, Weinblatt M, Robin JL, et al. Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. Arthritis Rheum 1987;30:988–97.
  97. Sperson GT, Grunne N, Lervang HH, et al. Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin Rheumatol 1992;11:393–5.
  98. Stenson WF, Eirt D, Rodgers J, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 1992;116:609–14.
  99. Stone J, Doube A, Dudson D, Wallace J. Inadequate calcium, folic acid, Vitamin E, zinc and selenium intake in rheumatoid arthritis patients: results of a dietary survey. Seminars in Arthritis and Rheumatism 27(3):180-185, 1997.
  100. Strange CJ. Coping with arthritis in its many forms. FDA Consumer. 1996;30(2).
  101. Taibi, DM, Bourguignon C, Taylor AG. Valerian use for sleep disturbances related to rheumatoid arthritis.* Holistic Nursing Practice. 2004;18(3):120-126.
  102. Tao X, Younger J, Fan FZ, et al. Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study.* Arthritis and Rheumatism. 2002;46(7):1735-1743.
  103. Van Der Temple H, Tulleken JF, Limburg PC, Muskiet FAJ, van Riiswijk MH. Defects of fish oil supplementation in rheumatoid arthritis. Ann Rheum Dis 1990;49:76–80.
  104. Van Tubergen A, van der Linden S. A brief history of spa therapy.* Annals of the Rheumatic Diseases. 2002;61(3):273-275.
  105. Verhagen AP, Bierma-Zeinstra SM, Cardoso JR, et al. Balneotherapy for rheumatoid arthritis. Cochrane Database of Systematic Reviews. 2005;(2):CD00518. Accessed on September 2, 2005.
  106. Wang C, Roubenoff R, Lau J, et al. Effect of tai chi in adults with rheumatoid arthritis.* Rheumatology (Oxford). 2005;44(5):685-687.