The most effective natural Enlarged Prostate treatment
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the most effective natural Enlarged Prostate treatment for you

WOMEN 39
AND UNDER		 MEN 39
AND UNDER		 WOMEN 40
AND UP		 MEN 40
AND UP
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What is an Enlarged Prostate?

An enlarged prostate or benign prostate hyperplasia (BHP) is an extremely common condition in men; eight% of all men between the ages of 31 and 40 and 50% of all men between the ages of 51 and 60 suffer from BPH.

Not all men suffering from an enlarged prostate have symptoms. Symptoms only occur when the size of the prostate is more than 30 ml. This in turn decreases urinary flow and results in nocturia (you have to get up at night to pass urine).

Men suffering from this condition may experience the following symptoms: frequent urination, nocturia, weak urinary flow, difficulty in initiating urination and difficulty in emptying the bladder completely.

Cause: The prostate gland keeps growing throughout a man's life, but in some men it grows faster and starts causing symptoms. Several scientific studies have proven that a number of natural ingredients are able to reduce symptoms, stop the growth and even reduce the size of the prostate without unpleasant side effects like impotence etc. Most pharmaceutical drugs used for this condition only reduce symptoms, not the size of the prostate and often cause side effects like impotence, lower libido, dizziness, headaches etc. The nutritional supplements mentioned below do not have these side effects.

Which natural ingredients can have an effect on an enlarged prostate?

Serenoa repens (saw palmetto), urtica dioca (nettle extract), lycopene, fish oils and zinc.

What effects do these ingredients have?

  • Just as effective as synthetic medicines but without side effects such as impotence, lowered libido, reduced ejaculation volume and rash.
  • Reduce prostate enlargement.
  • Enhance urinary flow.
  • Reduce residual urine.
  • Reduce nocturia.
  • Reduce frequent urination.
  • Stimulate libido.
  • Do NOT interfere with prostate specific antigen (PSA).

For the reader with a deeper interest:

How do these ingredients work?

  • Treat and prevent vitamin and mineral deficiencies.
  • Anti-estrogen and anti-spasmodic effect.
  • Anti-proliferate effect on epithelial and struma prostate cells.
  • Inhibit 5 alpha-reductase types 1 and 2.
  • Inhibit the conversion of testosterone to dihydrotestosteron (DHT).
  • Delay prostate cell growth by inhibiting fibroblast growth factor (FGF).
  • Reduce the tumor necrosis factor (TNF) alpha and interleukin (IL) 1 beta.
  • Inhibit lipoxygenase and cyclooxygenase (COX).

The information above is based on more than 6,200 articles published in scientific journals and which are available at MEDLINE. Below you will find a few of them listed:

References

  1. American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.
  2. Bach D, Ebeling L. Long-term drug treatment of benign prostatic hyperplasia—results of a prospective 3-year multicenter study using Sabal extract IDS 89. Phytomedicine 1996;3:105-11.
  3. Bayne CW, Donnelly F, Ross M, Habib FK. Serenoa repens (Permixon): a 5alpha-reductase types I and II inhibitor-new evidence in a coculture model of BPH. Prostate 1999;40:232-41.
  4. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 216-7.
  5. Boccafoschi C, Annoscia S. Comparison of Serenoa repens extract with placebo by controlled clinical trial in patients with prostatic adenomatosis [in Italian]. Urologia. 1983;50:1257-1268.**
  6. Brown D, Austin S, Reichert R. Benign Prostatic Hyperplasia and Prostate Cancer Prevention. Seattle: NPRC, 1997, 9-10.
  7. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publications, 1996, 167-72.
  8. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon®) with finasteride in the treatment of benign prostate hyperplasia: A randomized international study of 1,098 patients. Prostate 1996;29:231-40. **
  9. Champault G, Patel JC, Bonnard AM. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia. BrJ Clin Pharmacol. 1984;18:461-462.**
  10. Dathe G, Schmid H. Phytotherapy of benign prostate hyperplasia (BPH); double-blind study with stinging nettle root extract (Extractum Radicis Urticae - ERU) [translated from German]. Urologe B. 1987;27:223-226.***
  11. de la Taille A, Hayek OR, Burchardt M, Burchardt T, Katz AE. Role of herbal compounds (PC-SPES) in hormone-refractory prostate cancer: two case reports. J Altern Complement Med. Oct2000;6(5):449-51.
  12. Debruyne F, Koch G, Boyle P, et al. Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a one-year randomized international study. Eur Urol. 2002;41:497-507 **
  13. Delos S, et al. Testosterone Metabolism in Primary Cultures of Human Prostate Epithelial Cells and Fibroblasts. J Steroid Biochem & Molecular Biol. 1994;48(4):347-52.
  14. Descotes JL, Rambeaud JJ, Deschaseaux P, et al. Placebo-controlled evaluation of the efficacy and tolerability of PermixonW in benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug Invest. 1995;9:291-297.**
  15. Di Silverio F, et al. Evidence that Serenoa repens Extract Displays an Antiestrogenic Activity in Prostatic Tissue of Benign Prostatic Hypertrophy Patients. European Urologv. 1992;21(4):309-14.
  16. Di Silverio F, Monti S, Sciarra A, et al. Effects of long-term treatment with Serenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate 1998;37:77-83.
  17. Emili E, Lo Cigno M, Petrone U. Clinical trial of a new drug for treating hypertrophy of the prostate (PermixonW) [in Italian]. Urologia. 1983;50:1042-1048.**
  18. European Scientific Cooperative on Phytotherapy. Urticae radix. Exeter, UK: ESCOP, 1996-1997:4. Monographs on the Uses of Plant Drugs, Fascicule 2.
  19. Gerber GS, Kuznetsov D, Johnson BC, et al. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology. 2001;58:960-964.**
  20. Gerber GS, Zagaja GP, Bales GT, Chodak GW, Contreras BA. Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms. Urology. Jun1998;51(6):1003-7.
  21. Gerber GS. Saw palmetto for the treatment of men with lower urinary tract symptoms. J Urol. May2000;163(5):1408-12.
  22. Heinerman, John, 1996. Heinerman's Encyclopedia of Healing Herbs & Spices. Herb of the Month, May 1996, Urtica Dioca Monograph, Bastyr University, Department of Botanical Medicine.
  23. Hirano T, Homma M, Oka K. Effects of stinging nettle root extracts and their steroidal components on the Na+,K+-ATPase of the benign prostatic hyperplasia. Planta Med 1994;60:30-3.
  24. Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol. May2000;163(5):1451-6.
  25. Mattei FM, Capone M, Acconcia A, et al. Serenoa repens extract in the medical treatment of benign prostatic hypertrophy [in Italian]. Urologia. 1988;55:547-552. **
  26. Metzker H, Kieser M, Hölscher U. Efficacy of a combined Sabal-Urtica preparation in the treatment of benign prostatic hyperplasia (BPH).Urologe [B] 1996;36:292-300.
  27. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis.Planta Med 1990;56:44-7.
  28. Oertreis B, Giller K, Teucher T, et al. Antiphlogistic effects of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung 1996;46:52-6.
  29. Paubert-Braquet M, et al. Effect of Serenoa repens Extract (Permixon) on Stradiol/Testosterone-induced Experimental Prostate Enlargement in the Rat. Pharmacol Res. 1996;34(3-4):171-79.
  30. Plosker GL, Brogden RN. Serenoa repens (PermixonW). A review of its pharmacology and therapeutic efficacy in benign prostatic hyperplasia. Drugs Aging. 1996;9:379-395 **
  31. Porterfield H. UsToo PC-SPES surveys: review of studies and update of previous survey results. Mol Urol. Sep2000;4(3):289-91.
  32. Randall C, Meethan K, Randall H, Dobbs F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Compl Ther Med 1999;7:126-31.
  33. Ravenna L, et al. Effects of the Lipidosterolic Extract of Serenoa repens (Permixon) on Human Prostatic Cell Lines. Prostate. 1996;29(4):219-30.
  34. Sabal fructus (Saw Palmetto fruit). German Commission E Monograph. Mar1989:Bundesanzeiger, no. 43.
  35. Smith HR, Memon A, Smart CJ, et al. The value of PermixonW in benign prostatic hypertrophy. Br J Urol. 1986;58:36-40.**
  36. Sökeland J, Albrecht J. A combination of Sabal and Urtica extracts versus finasteride in BPH (stage I and II according to Alken): a comparison of therapeutic efficacy in a one-year double-blind study. Urologe [A] 1997;36:327-33.
  37. Strauch G, Perles P, Vergult G, et al. Comparison of finasteride (Proscar®) and Serenoa repens (Permixon®) in the inhibition of 5-alpha reductase in healthy male volunteers. Eur Urol 1994;26:247-52.
  38. Tasca A, Barulli M, Cavazzana A, et al. Treatment of obstructive symptomatology caused by prostatic adenoma using an extract of Serenoa repens. Double-blind clinical study vs. placebo [in Italian]. Minerva Urol Nefrol. 1985;37:87-91.**
  39. Tyler, Varro E., "Secondary Products: Physiologically Active Compounds, A Congress Review," HerbalGram 36, 60-61.
  40. Vontobel H, Herzog R, Rutishauser G, Kres H. Results of a double-blind study on the effectiveness of ERU (extractum radicis urticae) capsules in conservative treatment of benign prostatic hyperplasia. Urologe 1985;24:49-51 ***
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  43. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia. JAMA 1998;280:160-9. **